SS-31, also known as elamipretide, is a peptide studied in laboratory research for its potential role in mitochondrial function. It is a synthetic peptide that targets the inner mitochondrial membrane and is studied in research on cellular energy metabolism.
What Are the Key SS-31 Research Specifications?
| Specification | Research record |
|---|---|
| Compound | SS-31 |
| Category | longevity |
| Listed purity | >99% |
| Molecular weight | 639.8 g/mol |
| Intended use | Laboratory research only |
What Is the Chemical Structure of SS-31?
SS-31 is a small synthetic peptide with a molecular weight of approximately 639.8 g/mol. It is designed to interact with cardiolipin in the inner mitochondrial membrane, which is relevant to studies of mitochondrial function.
How Should SS-31 Analytical Quality Be Verified?
For SS-31, HPLC area purity should be read together with an orthogonal identity result. The SS-31 lot record should specify the molecular form, chromatographic method and intact-mass or spectroscopic confirmation. HPLC area alone does not establish SS-31 content, counterion, water, residual solvent or endotoxin; those variables can alter molar calculations and biological assays.
What Does Current Research Establish About SS-31?
SS-31 (elamipretide) is the aromatic-cationic tetrapeptide D-Arg-Dmt-Lys-Phe-NH2. It partitions to the inner mitochondrial membrane and interacts with cardiolipin; mitochondrial uptake should not be described as membrane-potential driven without testing.
A citable SS-31 evidence unit identifies the model, concentration, comparator, target-proximal readout and analytical identity. SS-31 results from animals, isolated cells and receptor assays answer different questions; they should not be collapsed into a medical claim or a single undifferentiated evidence tier.
What Should Researchers Report When Studying SS-31?
Define the complete SS-31 molecular form: sequence or structure, terminal modifications, counterion, formula mass and lot-specific content. Use a concentration-response series, time-matched vehicle and a target-dependent control rather than relying on a single descriptive phenotype. Verify SS-31 recovery at the working concentration, prepare single-use aliquots and avoid repeated freeze-thaw cycles. For cell assays, report endotoxin and serum conditions. HPLC area purity should be paired with intact-mass or spectroscopic identity and an assay appropriate to the proposed mechanism.
Where Can Researchers Verify SS-31 Sources?
Use PubMed’s indexed SS-31 literature to locate primary studies and PubChem’s SS-31 records to cross-check structures and identifiers. Match every citation to the exact sequence, ester, salt or formulation documented for the lot; a shared trade name does not prove chemical equivalence.
How Can SS-31 Results Be Interpreted Without Overclaiming?
Begin interpretation with a falsifiable question and a predeclared primary readout. For SS-31, chemical identity, target engagement and downstream phenotype are separate layers. A change in migration, viability or gene expression does not by itself prove the proposed molecular target. Report negative and null findings, not only the largest response. Show individual observations, biological replicates and uncertainty intervals, and identify whether replication means a new well, a new culture, a new animal or a new day.
A citable SS-31 result states the species, cell line or biochemical system; exact molecular form; concentration and exposure; comparator; assay method; and statistical unit. Confirm that vehicle, pH, osmolality or precipitation did not create the phenotype. Conclusions should stay at the level tested: in vitro activity is not evidence of organism-level efficacy, and an animal phenotype is not a human claim.
Is SS-31 for Research Use Only?
SS-31 is supplied for controlled laboratory research only. It is not intended for human or veterinary use. [Browse Longevity Peptides](/ longevity/)
What Are Common Questions About SS-31?
What is SS-31?
SS-31, also known as elamipretide, is a peptide studied in laboratory research for its potential role in mitochondrial function. It is a synthetic peptide that targets the inner mitochondrial membrane and is studied in research on cellular energy metabolism.
How should researchers verify SS-31?
Confirm the exact molecular form on the lot certificate and pair chromatographic purity with an orthogonal identity method such as mass spectrometry or NMR. Use the molecular weight, counterion and content stated for that verified form when calculating molarity.
Is SS-31 intended for human use?
SS-31 is listed for controlled laboratory research only. It is not intended for human or veterinary use.